Renal Denervation Reduces Monocyte Activation and Monocyte–Platelet Aggregate Formation

Renal Denervation Reduces Monocyte Activation and Monocyte–Platelet Aggregate Formation

Hypertension contributes significantly to the high cardiovascular morbidity and mortality rates worldwide. While acknowledging the complexity and multifactorial pathogenesis of hypertension, it has been suggested that activation of the sympathetic nervous system (SNS) is an important contributor in at least 50% of cases. Persistent sympathetic activation initiates and sustains elevated blood pr...

Renal Denervation Reduces Monocyte Activation and Monocyte-Platelet Aggregate Formation: An Anti-Inflammatory Effect Relevant for Cardiovascular Risk.

Overactivation of renal sympathetic nervous system and low-grade systemic inflammation are common features of hypertension. Renal denervation (RDN) reduces sympathetic activity in patients with resistant hypertension. However, its effect on systemic inflammation has not been examined. We prospectively investigated the effect of RDN on monocyte activation and inflammation in patients with uncont...

Platelet activation and platelet- monocyte aggregate formation induced by the atherosclerotic plaque lipid lysophosphatidic acid

Renal Denervation

Type 2 diabetes mellitus (T2DM) is a group of metabolic diseases of multiple etiologies. Although great progress has been made, researchers are still working on the pathogenesis of T2DM and how to best use the treatments available. Aside from several novel pharmacological approaches, catheter-based sympathetic renal denervation (RDN) has gained a significant role in resistant hypertension, as w...

Endocannabinoids Control Platelet Activation and Limit Aggregate Formation under Flow

BACKGROUND The endocannabinoid system has previously been implicated in the regulation of neurons and inflammatory cells. Additionally, it has been reported that endocannabinoid receptors are present on circulating platelets, but there has been conflicting evidence on their contribution to platelet function. OBJECTIVES Our aim was to examine the role of endocannabinoids in platelet function i...